Evaluation of anticonvulsant activity of methanol leaf extract of Opilia celtidifolia diels (opiliaceae) in mice and chicks

Epilepsy affects 1% of the global population, with around 2.4 million new diagnoses annually. Approximately 80% individuals epilepsy reside in low- and middle-income countries, a prevalence 8.2 per 1000 sub-Saharan Africa 8 Nigeria. This study evaluated anticonvulsant properties methanol leaf extract Opilia celtidifolia (MEC) mice chicks. The median lethal dose (LD50) was determined acute MEC were using pentylene tetrazole (PTZ), maximal electroshock (MES), strychnine, picrotoxin-induced convulsions, while chronic effect assessed through PTZ-induced kindling. effects on cognition, coordination, motor deficits, sedation, locomotion Y Maze, Beam Walking, Open Field tests. increased mean percentage survival significantly delayed onset seizure (p<0.05), strychnine-induced (p<0.01), seizures (p<0.05) at mg/kg. However, did not provide protection against MES-induced seizures. In kindling model, extract-treated exhibited decrease threshold, an associated increase oxidative stress. treated showed significant locomotor activity apparent sedative but there no obvious cognitive impairment learning memory, coordination or deficits. is apparently non-toxic possesses some animal models epilepsy. It also decreased mice.